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In Sequence: The Unseen Commitment to Quality at MicroGenDX When you receive your test results from MicroGenDX, you are seeing the final product of a comprehensive lab quality journey that began long before your sample arrived at our laboratory. What you don’t see are the countless hours of validation, the daily quality checks, the rigorous training programs, and the unwavering commitment to accuracy that happens behind our laboratory doors. Let’s pull back the curtain and show you what really goes on in our lab. The Foundation: Test Validation and Development Before any of our tests are approved for real world […]

Synovial NGS Concordance with ICM Criteria for PJI Diagnosis Periprosthetic joint infection (PJI) is one of the most consequential complications of hip and knee arthroplasty, and it is also one of the hardest to confirm. No single test settles the question on its own. The International Consensus Meeting 2018 (ICM-18) definition addresses this by combining major and minor criteria, yet major criteria such as two phenotypically matching positive cultures or a sinus tract communicating with the joint are not met in up to 29 percent of cases (Sigmund et al., 2022). Culture-negative PJI compounds the problem, occurring in roughly 28 […]

Critical Care  ·  NGS in Pleural Fluid  When Pleural Fluid Culture Falls Short.  A 145-specimen ICU evaluation found targeted next-generation sequencing detected pathogens in exudative pleural fluid roughly three times more often than standard culture. Here is what the evidence shows, and where it fits.  Source  Lopez-Ruiz et al., AJRCCM 2026 (ATS 2026)     Cohort  AdventHealth ICU · n = 145     Topic  Culture-negative pleural infection    CLINICAL CONTEXT  The Clinical Problem  A patient in the ICU has a large pleural effusion. Imaging, inflammatory markers, and the clinical course all point toward infection. The pleural fluid is drained, sent for culture, and […]