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All Published Studies
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Wound
| An antimicrobial prophylaxis protocol using rectal swab cultures for transrectal prostate biopsy |
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Aims The diagnosis of periprosthetic joint infection can be difficult due to the high rate of culturenegative infections. The aim of this study was to assess the use of next-generation sequencing for detecting organisms in synovial fluid. |
| "We have the option for 100% effective treatment." Beth Pearce, DPM |
| "We have the option for 100% effective treatment." An Interview with Beth Pearce, DPM |
| "We have been waiting for technology like this." Javad Parvizi, MD |
| "This made a significant difference in the patient's care and his outcome." Michael Waters, DO |
| "This is the best my sinus has been in my entire adult life." Laurence O'Halloran, MD talks about his patient's success using MicroGen DX |
| "You can identify it, you treat it, now you're able to better heal it." Matthew Regulski, DPM |
| The MicroGen DX Laboratory: Next-Gen Sequencing; Superior Diagnostics Simplified |
| "This is a huge change where we can diagnose these patients earlier." An interview with Michael McDonald, MD |
| Identifying the causative microbes of infections with Next-Gen Sequencing- Andrew Pugliese M.D. |
| "This revolutionized the way I practice the management of chronic infections" Andrew Pugliese, MD |
| Diagnosis of Streptococcus canis periprosthetic joint infection: the utility of next-generation sequencing |
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Aims The diagnosis of periprosthetic joint infection can be difficult due to the high rate of culturenegative infections. The aim of this study was to assess the use of next-generation sequencing for detecting organisms in synovial fluid. |
| A Pilot Study to Evaluate Next Generation DNA Sequencing Testing to Rectal Swabs |
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Aims The diagnosis of periprosthetic joint infection can be difficult due to the high rate of culturenegative infections. The aim of this study was to assess the use of next-generation sequencing for detecting organisms in synovial fluid. |
| Diagnosis of Periprosthetic Joint Infection: The Potential of Next-Generation Sequencing |
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Aims The diagnosis of periprosthetic joint infection can be difficult due to the high rate of culturenegative infections. The aim of this study was to assess the use of next-generation sequencing for detecting organisms in synovial fluid. |
| More than meets the eye: Innovative technology spots bacteria previously undetected |
| Can next generation sequencing play a role in detecting pathogens in synovial fluid? |
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Aims The diagnosis of periprosthetic joint infection can be difficult due to the high rate of culturenegative infections. The aim of this study was to assess the use of next-generation sequencing for detecting organisms in synovial fluid. |
| "We started doing the DNA sequencing... and were AMAZED." Michael Lavor, MD |
| "I trust it implicitly" Margarita Johnson, MD |
| "MicroGen DX gives us the right key." Nabeel Syed, MD |
| “With this test, you’re going to be the hero.” Roscoe Nelson, MD |
| "With this test, you're going to be the hero." Roscoe Nelson, MD |
| “I feel proud that I can get this treatment to the patients.” Lisa Zambrano, NP |
| "I feel proud that I can get this treatment to the patients." Lisa Zambrano, NP |
| “It’s inordinately valuable for patients.” Keith Matheny, MD |
| "It's inordinately valuable for patients." Keith Matheny, MD |
| “It’s a win for me, it’s a win for the patient.” Lyle Haskell, D.P.M |
| "It's a win for me, it's a win for the patient." Lyle Haskell, D.P.M |
| “Truly, it’s precision medicine.” Robert Dean, MD |
| "Truly, it's precision medicine." Robert Dean, MD |
| “MicroGen DX is absolutely a key part of our whole management strategy.” Jon Minter, DO |
| "MicroGen DX is absolutely a key part of our whole management strategy." Jon Minter, DO |
| “It is going help me, help my patients.” Ginger Isom-Batz, MD |
| "It is going help me, help my patients." Ginger Isom-Batz, MD |
| “This has revolutionized my practice, it will revolutionize your practice.” Timothy Hlavinka, MD |
| "This has revolutionized my practice, it will revolutionize your practice." Timothy Hlavinka, MD |
| Comparative Phase II Study of Standard Urine C&S vs DNA NGS Testing for UTIs |
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Aims The diagnosis of periprosthetic joint infection can be difficult due to the high rate of culturenegative infections. The aim of this study was to assess the use of next-generation sequencing for detecting organisms in synovial fluid. |
| MicroGenDX featured on LifeTime Television |
| MicroGenDX featured on LifeTime Television |
| Live UTI Free on MicroGenDX |
| Use of Dipstick Assay and Rapid PCR-DNA Analysis of Nasal Secretions for Diagnosis of Bacterial Sinusitis in Children With Chronic Cough |
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Aims The diagnosis of periprosthetic joint infection can be difficult due to the high rate of culturenegative infections. The aim of this study was to assess the use of next-generation sequencing for detecting organisms in synovial fluid. |
| “Why aren’t you using this?” Eric L. Johnson, M.D. |
| General Assembly, Diagnosis, Pathogen Isolation: Proceedings of International Consensus on Orthopedic Infections |
| Determining the utility of standard hospital microbiology testing: Comparing standard microbiology cultures with DNA sequence analysis in patients with chronic sinusitis |
| Metagenomics in diagnosis and improved targeted treatment of UTI |
| MicroGenDX's Next-Generation DNA Sequencing Ushers in New Era of Advanced Infection Diagnostics at 2019 American Academy of Orthopedic Surgeons with Multiple Podium Talks |
| NEXT GENERATION SEQUENCING OF MICROBIOMES IN POST-DRE URINE SAMPLES OF PROSTATE CANCER PATIENTS |
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Introduction : Pathogenic microorganisms could be responsible for asymptomatic and symptomatic inflammatory processes in the prostate including Escherichia coli, Pseudomonas spp., Neisseria gonorrhoeae, Trichomonas vaginalis, etc (1). Modifications of bacterial populations were observed according to different inflammatory and tumor conditions in prostate cancer (PCa) samples, which may promote the development of cancer by enhancing extracellular environmental factors within the prostate (2-4). E. David Crawford, M.D, Rick Martin, Caleb D. Phillips, Ph.D., Whitney N. Stanton, Adrie van Bokhoven, Ph.D., M. Scott Lucia, M.D., Paul Arangua, Francisco G. La Rosa, M.D., Zachary Grasmick, Gretchen Hoyer, Vladimir Mouraviev, M.D., Ph.D., Nelson N. Stone, M.D., Priya N. Werahera, Ph.D. |
| Evaluation of the bacterial diversity of pressure ulcers using bTEFAP pyrosequencing |
BMC Medical GenomicsDrake M Smith1, David E Snow1, Eric Rees1, Ann M Zischkau1, J Delton Hanson1, Randall D Wolcott2, Yan Sun1, Jennifer White1, Shashi Kumar1, Scot E Dowd1,3*Click Here to View Study |
| Evaluation of bacterial diversity in the feces of cattle using 16S rDNA bacterial tag-encoded FLX amplicon pyrosequencing (bTEFAP) |
BMC MicrobiologyScot E Dowd*1,3,4, Todd R Callaway2, Randall D Wolcott3, Yan Sun3, Trevor McKeehan3, Robert G Hagevoort5 and Thomas S Edrington2Click Here to View Study |
| Evaluation of the bacterial diversity among and within individual venous leg ulcers using bacterial tag-encoded FLX and Titanium amplicon pyrosequencing and metagenomics approaches |
BMC MicrobiologyRandall D Wolcott1,2, Viktoria Gontcharova3, Yan Sun3 and Scot E Dowd*2,3Click Here to View Study |
| Polymicrobial Nature of Chronic Diabetic Foot Ulcer Biofilm Infections Determined Using Bacterial Tag Encoded FLX Amplicon Pyrosequencing (bTEFAP) |
PLoS OneScot E. Dowd1,3*, Randall D. Wolcott2, Yan Sun1, Trevor McKeehan1, Ethan Smith3, Daniel Rhoads2Click Here to View Study |
| Identification of yeast in chronic wounds using new pathogen-detection techniques |
Journal of Wound Care, Vol.18, No.3J.L. Leake, S.E. Dowd, R.D. Wolcott, A.M. Zischkau, Y. SunClick Here to View Study |
| In vitro multispecies Lubbock chronic wound biofilm model |
Wound Repair and RegenerationYan Sun, PhD1; Scot E. Dowd, PhD1; Ethan Smith, BSc1; Dan D. Rhoads, MTC2; Randall D. Wolcott, MD2Click Here to View Study |
| Survey of bacterial diversity in chronic wounds using Pyrosequencing, DGGE, and full ribosome shotgun sequencing |
BMC MicrobiologyScot E Dowd*1, Yan Sun2, Patrick R Secor3, Daniel D Rhoads2, Benjamin M Wolcott2, Garth A James3 and Randall D Wolcott2Click Here to View Study |
| Healing and healing rates of chronic wounds in the age of molecular pathogen diagnostics |
Journal of Wound CareWolcott RD, Cox SB, Dowd SEClick Here to View Study |
| Clinical identification of bacteria in human chronic wound infections: culturing vs 16S ribosomal DNA sequencing |
BMC Infectious DiseasesDaniel D Rhoads1, Stephen B Cox2, Eric J Rees2, Yan Sun2 and Randall D Wolcott2,3,4*Click Here to View Study |
| Molecular diagnostics and personalized medicine in wound care: assessment of outcomes |
Journal of Wound Care, Vol.20, No.5S.E. Dowd,1 PhD, Research Director; R.D. Wolcott,2 MD, Medical Director; J. Kennedy,3 PhD, R.Ph.; C. Jones,3 PhD, R.Ph; S.B. Cox,4 PhDClick Here to View Study |
| Determining the utility of standard hospital microbiology testing: Comparing standard microbiology cultures with DNA sequence analysis in patients with chronic sinusitis |
World Journal of Otorhinolaryngology Head and Neck SurgerySarah K. Rapoport a,*, Alyssa J. Smith b, Maxwell Bergman c,Kelly A.Scriven a, Itzhak Brook d, Suzette K. Mikula aClick Here to View Study |
| Comparison of Culture and Molecular Identification of Bacteria in Chronic Wounds |
International Journal of Molecular SciencesDaniel D. Rhoads 1,2, Randall D. Wolcott 1,3,4,*, Yan Sun 3 and Scot E. Dowd 3,4Click Here to View Study |
| Culture Enriched Molecular Profiling of the Cystic Fibrosis Airway Microbiome |
PLoS OneChristopher D. Sibley1, Margot E. Grinwis1, Tyler R. Field1, Christina S. Eshaghurshan1, Monica M. Faria1, Scot E. Dowd4,5, Michael D. Parkins1,2,3, Harvey R. Rabin1,2,3, Michael G. Surette1,6*Click Here to View Study |
| An in vivo Polymicrobial Biofilm Wound Infection Model to Study Interspecies Interactions |
PLoS OneTrevor Dalton1,2, Scot E. Dowd3, Randall D. Wolcott3, Yan Sun3, Chase Watters1,2, John A. Griswold1, Kendra P. Rumbaugh1,2*Click Here to View Study |
| Microbiota is a primary cause of pathogenesis of chronic wounds |
Journal of Wound Care, Vol.25, No.10Wolcott R1, Sanford N1, Gabrilska R2, Oates JL3, Wilkinson JE3, Rumbaugh KP2Click Here to View Study |
| The presence of biofilm structures in atherosclerotic plaques of arteries from legs amputated as a complication of diabetic foot ulcers |
Journal of Wound Care, Vol.25, No.2D.E. Snow1, J. Everett2, G. Mayer1, S.B. Cox3, B. Miller5, K. Rumbaugh2, R.A. Wolcott3Click Here to View Study |
| Analysis of the chronic wound microbiota of 2,963 patients by 16S rDNA pyrosequencing |
Wound Repair and RegenerationRandall D. Wolcott, MD1†; John D. Hanson, PhD2†; Eric J. Rees, PhD2†; Lawrence D. Koenig, PhD2†; Caleb D. Phillips, PhD2†; Richard A. Wolcott, PhD2,3†; Stephen B. Cox, PhD2†; Jennifer S. White, MS3†Click Here to View Study |
| Comparative study of cultures and next-generation sequencing in the diagnosis of shoulder prosthetic joint infections |
Journal of Shoulder and Elbow SurgerySurena Namdari, MD, MSc*, Thema Nicholson, MSc, Joseph Abboud, MD, Mark Lazarus, MD, Matthew L. Ramsey, MD, Gerald Williams, MD, Javad Parvizi, MDClick Here to View Study |
| Diagnosis of Periprosthetic Joint Infection: The Potential of Next-Generation Sequencing |
The Journal of Bone and Joint Surgery, Inc.Majd Tarabichi, MD, Noam Shohat, MD, Karan Goswami, MD, Abtin Alvand, MD, PhD, FRCS, Randi Silibovsky, MD, Katherine Belden, MD, and Javad Parvizi, MD, FRCSClick Here to View Study |
| An implementation of next generation sequencing for prevention and diagnosis of urinary tract infection in urology |
The Canadian Journal of UrologyVladimir Mouraviev, MD1, Michael McDonald, MD2Click Here to View Study |
| A Head-to-Head Comparative Phase II Study of Standard Urine Culture and Sensitivity Versus DNA Next-Generation Sequencing Testing for Urinary Tract Infections |
Reviews in Urology, Vol.19, No.4Michael McDonald, MD,1,2 Darian Kameh, MD,3 Mark E. Johnson, PhD,4 Truls E. Bjerklund Johansen, MD, DMSci,5 David Albala, MD,6 Vladimir Mouraviev, MD, PhD7,8Click Here to View Study |
| MP15-14 The value of next generation DNA sequencing testing in rectal swabs before transrectal prostate biopsy for individual and targeted prophylaxis of urinary tract infection |
The Journal of Urology, Vol.199, No.4SVladimir Mouraviev*, Davenport, FL; Michael W. McDonald, Celebration, FL; Colby Skinner, Orlando, FL; Srinivas Vourganti, Chicago, IL; David M. Albala, Syracuse, NY; Kurt Naber, Munich, Germany; Florian M. E. Wagenlehner, Giessen, Germany; Truls E. Bjerklund Johansen, Oslo, NorwayClick Here to View Study |
| MP23-06 An utilization of next generation sequencing of urine samples for monitoring of urinary tract infections in patients with neurogenic bladder |
The Journal of Urology, Vol.199, No.4SYan Liu*, Ellen Shapiro, Herbert Lepor, Tung-Tien Sun, Xue-Ru Wu, New York, NYClick Here to View Study |
| Metagenomics in diagnosis and improved targeted treatment of UTI |
World Journal of UrologyMatthew Dixon1, Maria Stefil1, Michael McDonald2,3, Truls Erik Bjerklund‑Johansen4, Kurt Naber5, Florian Wagenlehner6, Vladimir Mouraviev2,3,7Click Here to View Study |
| Can next generation sequencing play a role in detecting pathogens in synovial fluid? |
The Bone & Joint JournalTarabichi, N. Shohat, K. Goswami, J. ParviziClick Here to View Study |
| Diagnosis of Streptococcus canis periprosthetic joint infection: the utility of next-generation sequencing |
Arthroplasty TodayMajd Tarabichi, MD, Abtin Alvand, MD, PhD, FRCS (Tr&Orth), Noam Shohat, MD, Karan Goswami, MD, Javad Parvizi, MD, FRCSClick Here to View Study |
| Use of Dipstick Assay and Rapid PCR-DNA Analysis of Nasal Secretions for Diagnosis of Bacterial Sinusitis in Children With Chronic Cough |
Allergy and RhinologyCharles Song, MD1, Jeena Chorath, MD1, Youngju Pak, PhD1, and Nasser Redjal, MD1Click Here to View Study |
| The Potential of High-Throughput DNA Sequencing of the Paranasal Sinus Microbiome in Diagnosing Odontogenic Sinusitis |
American Academy of Otolaryngology–Head and Neck Surgery FoundationAsad A. Haider1, Michael J. Marino, MD2, William C. Yao, MD1, Martin J. Citardi, MD1, and Amber U. Luong, MD, PhD1,3Click Here to View Study |
| MP47-07 Comparative Value of Chronic Urinary Tract Infection (UTI) Diagnosis Between Standard Culture Sensitivity and Next Generation Sequence (NGS) in Urine Samples |
The Journal of Urology, Vol.201, No.4SGeorge Coba*, Timothy Koo, Saif Zaman, Tampa, FL; Maria Stefil, Matthew Dixon, Norwich, United Kingdom; Liqiang Ni, Orlando, FL; Michael McDonald, Celebration, FL; Vladimir Mouraviev, Orlando, FLClick Here to View Study |
| MP71-03 Comparison of Novel DNA-Based Tools for Bacterial Detection in Patients with Chronic Urinary Tract Infection (CUTI) |
The Journal of Urology, Vol.201, No.4SGeorge Coba*, Timothy Koo, Saif Zaman, Tampa, FL; Maria Stefil, Matthew Dixon, Norwich, United Kingdom; Liqiang Ni, Orlando, FL; Michael McDonald, Celebration, FL; Vladimir Mouraviev, Orlando, FLClick Here to View Study |
| MicroGenDX Next-Generation DNA Sequencing to Take Center Stage at American Association of Hip and Knee Surgeons to Reveal New Findings in Periprosthetic Joint Infection |
| MicroGenDX Next-Gen DNA Sequencing Used in Breakthrough Knee Infection Study: Rothman Institute Accepts Eastern Orthopaedic Association’s Musculoskeletal Infection Award |