Infectious Disease & Microbiologist Related Information

Our philosophy here is, we need to stay on the cutting edge of technology. And we've realized that molecular is not only now the future, but it will continue to be the future."

James Snyder, Ph. D.
Professor of Pathology & Laboratory Medicine
University of Louisville Hospital

Ten Years' Experience Offers Speed & Accuracy


College of American Pathology (CAP) Proficiency Results

Microbial Identification to the Species Level Using NGS 2009 - 2018

Species PanelTest FrequencyNumber of Blinded Samples per TestNumber of Blinded SpecimensProficiency Score
IDR3 Times per year for 5 years57597.3%
MRS-5 (M)3 Times per year for 10 years5150100.0%
F13 Times per year for 10 years515098.0%
D83 Times per year for 10 years515099.3%
VRE3 Times per year for 10 years240100.0%
GIP3 Times per year for 2 years530100.0%
HC-63 Times per year for 1 year515100.0%
TVAG3 Times per year for 1 year39100.0%
Alternate3 Times per year for 10 years6180100.0%
Blinded Specimens Total 799Mean Accuracy Rate 99.4%

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Turn to Next-Gen DNA Sequencing (NGS) for More Answers!

Use NGS on sites of suspected infections:

  • Prosthetic joint infections
  • Chronic bacterial prostatitis
  • Chronic UTIs
  • Endocarditis
  • Hardware infections
  • Spine infections
  • ...and more!


MicroGenDX, market leader in molecular diagnostics for infections.


MicroGenDX is the only laboratory using PCR Rapid Screening & Next-Gen DNA Sequencing

For fast delivery of the most comprehensive microbial reports on the market!

Most experienced lab with more than 400k samples processed

  • Provide antibiotic resistance genes for 10 classes of antibiotics
  • Fastest turnaround of results (3.5 days)
  • Least expensive lab in the world for PCR + NGS ($250/patient)
  • The most published clinical trials
  • The only NGS lab with published data showing 96.1% concordance with culture


Arthroplasty Today (2017)

Diagnosis of Streptococcus Canis Periprosthetic Joint Infection: The Utility of Next-Generation Sequencing

Majd Tarabichi, MD; Abtin Alvand, MD, PhD, FRCS (Tr&Orth); Noam Shohat, MD; Karan Goswami, MD; Javad Parvizi, MD, FRCS

The Journal of Bone and Joint Surgery (2018)

Can Next Generation Sequencing Play a Role in Detecting Pathogens in Synovial Fluid?

Majd Tarabichi, MD; Noam Shohat, MD; Karan Goswami, MD; Javad Parvizi, MD, FRCS

The Journal of Bone and Joint Surgery (2018)

Diagnosis of Periprosthetic Joint Infection: The Potential of Next-Generation Sequencing

Majd Tarabichi, MD; Noam Shohat, MD; Karan Goswami, MD; Abtin Alvand, MD, PhD, FRCS; Randi Silibovsky, MD; Katherine Belden, MD; and Javad Parvizi, MD, FRCS

Reviews in Urology (2017)

A Head-to-Head Comparative Phase II Study of Standard Urine Culture and Sensitivity Versus DNA Next-Generation Sequencing Testing for Urinary Tract Infections

Michael McDonald, MD; Darian Kameh, MD; Mark E. Johnson, PhD; Truls E. Bjerklund Johansen, MD, DMSci; David Albala, MD; Vladimir Mouraviev, MD, PhD



1How can NGS technology replace traditional cultures when it doesn’t provide antibiotic sensitivities?

We do provide antibiotic resistance by detection of the resistant gene for eight antibiotic classes and two additional in development.

Culture sensitivities can only be performed if you can “grow” the microbe.

Being able to culture “grow” a microbe is not the determining factor to verify if the species is a problem for the host.

Only 1% of all known microorganisms can be grown in culture.

We currently know the sequence codes for more than 30,000 species.

ESCMID guidelines make the point that antibiotic sensitivities have no clinical value when treating a biofilm infection.

Breakpoints to determine S-I-R have been established for planktonic bacteria; however, breakpoints haven’t been established for the biofilm or community of microorganisms.

2How do you determine if the bacteria species are viable?
After the cell wall is ruptured, the DNA begins to degrade. DNA that is degrading results in poor quality reads, making it impossible to identify the species. We need good quality reads to determine microbial species.
3Interpretation of the lab report — what does all this mean?

The Next-Gen DNA Sequencing report is one piece of diagnostic information and should be used with other diagnostics criteria for infection — such as CRP, WBC, LE, and other biomarkers. In chronic infections it is often a collaborative community of microbes that causes the infection, not the single planktonic bacteria. The community will make the determination to switch to pathogenic mode. NGS allows the clinician to understand the complete makeup of the community.

Bacteria form biofilms/collaborative communities and the indication of becoming pathogenic is determined by their community.

CDC and NIH have estimated that biofilm infections now constitute 65% to 80% (respectively) of bacterial infections treated by physicians in the developed world.

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