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PRIMARY CARE | qPCR + NGS for Primary Care Infections

Fast + Comprehensive:  Two Molecular Technologies

The qPCR + NGS solution

qPCR vs NGS

MicroGenDX qPCR+ NGS offers you two detailed diagnostic reports in rapid succession.

The first, a qPCR report in 24-48 hours, provides total bacterial load, any antimicrobial resistance genes present, and detection of a few known pathogens. Physicians find the antimicrobial resistance genes helpful for patients who are already on antimicrobial treatment. However, qPCR will only detect the commonly-known microbes selected for a limited qPCR panel. Because of this, qPCR by itself can miss the dominant species in the sample up to 60% of the time. Which means that initiation of new antimicrobials is not recommended prior to receiving the NGS report that follows.

The second report provides next-generation sequencing (NGS) results in 3.5 days. This includes everything in the qPCR report, plus a complete list of clinically relevant microbes in the sample — and their abundance distribution — using NGS. These microbes are referenced against a custom database of over 50,000 species. In addition, the qPCR+NGS report offers research-based antimicrobials for consideration, based on the Sanford Guide and Johns Hopkins Guides. These combined qPCR+NGS results provide detailed and accurate clinical diagnostic information for the most confident treatment decisions.

 qPCRNGS
Results in24-48 hours3.5 days
Information provided

  • Up to 17 antimicrobial resistance genes for all classes of antimicrobials

  • Microbial loads of detected microbes

  • Narrowly targeted common pathogens associated with acute infection


  • Complete list of clinically relevant bacteria and fungi in the sample

  • Relative abundance of detected microbes, allowing determination of dominant species

Treatment considerations

  • Physicians find the antimicrobial resistance genes helpful for patients who are already receiving antimicrobial treatment

  • qPCR by itself is narrowly targeted, and can miss the dominant species in a sample up to 60% of the time, which means that initiation of new antimicrobials is not recommended prior to receiving the NGS report that follows



  • Research-based antimicrobials for consideration, based on Sanford Guide and Johns Hopkins Guides

  • More comprehensive insight into biocommunity at infection site

References

  1. Matthew Dixon, Maria Stefil, Michael McDonald, Truls Erik Bjerklund-Johansen , Kurt Naber, Florian Wagenlehner, Vladimir Mouraviev. Metagenomics in diagnosis and improved targeted treatment of UTI. World J Urol . 2020 Jan;38(1):35-43. doi: 10.1007/s00345-019-02731-9.
  2. Internal competitive analysis of qPCR and NGS – data on file.
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