MicroGenDX Published Studies

January 1, 2018
A-Pilot-Study-to-Evaluate-Next-Generation-DNA-Sequencing-Testing-to-Rectal-Swabs-prior-to-Transrectal-Prostate-Biopsy-for-Cancer-Screening-and-Diagnosis

A Pilot Study to Evaluate Next Generation DNA Sequencing Testing to Rectal Swabs

Introduction and Objective:

The introduction of next generation sequencing (NGS) via DNA technology allows us to analyze the complete genomic profile of the gut microbiota with detection of resistance genes to the most frequently used antibiotics in empiric prophylaxis.

V. Mouraviev1, M. W. McDonald , S.Vourganti, D.M.Albala, F.M.E. Wagenlehner, K. G.Naber, T. E. Bjerklund Johansen, Whitney Stanton, Gretchen Hoyer, E. D. Crawford

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August 1, 2017
Strep-Canis-Case-Arthroplasty-today-2017-1-1-thumb

Diagnosis of Streptococcus canis periprosthetic joint infection: the utility of next-generation sequencing

Abstract

A 62-year-old man who had undergone a primary knee arthroplasty 3 years earlier, presented to the emergency department with an infected prosthesis. He underwent prosthesis resection. All cultures failed to identify the infecting organism. Analysis of the intraoperative samples by next-generation sequencing revealed Streptococcus canis (an organism that resides in the oral cavity of dogs).

Majd Tarabichi, MD, Abtin Alvand, MD, PhD, FRCS (Tr&Orth), Noam Shohat, MD, Karan Goswami, MD, Javad Parvizi, MD, FRCS

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January 1, 2017
Assessment-of-Prostate-Cancer-Risk-in-Men-with-PSA--1.5-_Third-Global-Summit-on-Precision-Diagnosis-and-Treatment-of-Prostate-Cancer

Assessment of Prostate Cancer Risk in Men with PSA < 1.5

Introduction and Objective:

Prostate Specific Antigen (PSA) screening remains controversial primarily because of over detection and over treatment. There is an unmet clinical need to identify patients at increased risk for high-grade (HG – Gleason Score ≥7) prostate cancer (PCa) since PSA has low sensitivity.

Whitney N. Stanton, E. David Crawford, MD, Paul Arangua, John Hoenemeyer, MD, Francisco G. La Rosa, MD, Adrie van Bokhoven, PhD, M. Scott Lucia, MD, Wendy Poage1, Gretchen Hoyer, and Priya N. Werahera, PhD

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May 1, 2015

An antimicrobial prophylaxis protocol using rectal swab cultures for transrectal prostate biopsy

Abstract

Purpose To evaluate the benefit of an antimicrobial prophylaxis protocol using rectal swab cultures in patients undergoing transrectal ultrasound (TRUS)-guided prostate biopsy in our Veterans Affairs population.

Stephen J. Summers, Darshan P. Patel, Blake D. Hamilton, Angela P. Presson, Mark A. Fisher, William T. Lowrance, Andrew W. Southwick

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