Next-generation sequencing is a well-established technique for sequencing of DNA and has recently gained attention in many fields of medicine. Our aim was to evaluate the accuracy of next-generation sequencing in identifying the causative organism(s) in patients with periprosthetic joint infection.
Majd Tarabichi, MD, Noam Shohat, MD, Karan Goswami, MD, Abtin Alvand, MD, PhD, FRCS, Randi Silibovsky, MD, Katherine Belden, MD, and Javad Parvizi, MD, FRCS
The diagnosis of periprosthetic joint infection can be difficult due to the high rate of culturenegative infections. The aim of this study was to assess the use of next-generation sequencing for detecting organisms in synovial fluid…
M. TARABICHI, N. SHOHAT, K. GOSWAMI, J. PARVIZI
Prophylactic Antibiotics for Prostate Biopsy
The discussion regarding the best strategies for selecting prophylaxis for prostate biopsies to minimize infectious complications continued in this year’s sessions. One group reported on the use of next generation DNA sequencing to test rectal swabs for the purpose of tailoring the prebiopsy antibiotic regimen (MP15- 14). Infectious complications were avoided in 23 of 24 patients, with only a single patient having cystitis 3 weeks after biopsy
Many studies have discussed clinical practice guidelines for the treatment of cystitis and pyelonephritis. Treatment of uncomplicated urinary tract infections (UTIs) can be based on empiric antibiotic therapy.
Michael McDonald, MD, Darian Kameh, MD, Mark E. Johnson, PhD, Truls E. Bjerklund Johansen, MD, DMSci, David Albala, MD, Vladimir Mouraviev, MD, PhD