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Interpreting Your qPCR+NGS Level 2 Report

lab report sample

What do these results tell us?

Once they have penetrated the epithelial layer, normal commensal cells always cause destructive infections. The sustained presence of proinflammatory agents due to bacterial colonization causes extracellular matrix degradation, inhibits cell migration, and prevents wound closure.

  1. Antibiotic resistance genes reveal the resistance potential within a sample’s microbial community, indicating which antibiotics’ effects would be reduced.
  2. Total microbial load represents the number of viable DNA copies per mL.
  3. A complete list of clinically-relevant microbes detected in the sample:
    1. The more dominant Finegoldia magna and Corynebacterium striatum were only detected by NGS
    2. Staphylococcus aureus was detected by qPCR
    3. Microbial abundance distribution informs treatment decisions
  4. Evidence-based antimicrobials for consideration, based on Sanford Guide and Johns Hopkins Guides (Infectious Disease consultations also available). Not determined by phenotypic susceptibility analysis.

“If I'm going to do a skin graft, and I have any question about infection at all, I'll do the DNA sequencing.”

– Michael Lavor, MD

Medical Director, Saguaro Surgical, Tucson, AZ