UROLOGY | qPCR + NGS for Urology

Fast + Comprehensive:  Two Molecular Technologies

The qPCR + NGS solution

qPCR vs NGS

MicroGenDX offers you two detailed diagnostic reports in rapid succession.

The first, a qPCR report in 24-48 hours, provides antimicrobial resistance genes and the total microbial loads of a few known pathogens. Physicians find the antimicrobial resistance genes helpful for patients who are already on antimicrobial treatment. However, qPCR will only detect the commonly-known microbes selected for a limited qPCR panel. Because of this, qPCR by itself can miss the dominant species in the sample up to 60% of the time. Which means that initiation of new antimicrobials is not recommended prior to receiving the NGS report that follows.

The second report provides next-generation sequencing (NGS) results in 3.5 days. This includes everything in the qPCR report, plus a complete list of clinically relevant microbes in the sample — and their abundance distribution — using NGS. These microbes are referenced against a custom database of 50,000 species. In addition, the qPCR + NGS report offers research-based antimicrobials for consideration, based on the Sanford Guide and Johns Hopkins Guides. These combined qPCR+NGS results provide detailed and accurate clinical diagnostic information for the most confident treatment decisions.

References

  1. Matthew Dixon, Maria Stefil, Michael McDonald, Truls Erik Bjerklund-Johansen , Kurt Naber, Florian Wagenlehner, Vladimir Mouraviev. Metagenomics in diagnosis and improved targeted treatment of UTI. World J Urol . 2020 Jan;38(1):35-43. doi: 10.1007/s00345-019-02731-9.
  2. Internal competitive analysis of qPCR and NGS – data on file.
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