51 results found for: Periprosthetic joint infection
We were fortunate enough to be able to sit down with Javad Parvizi recently for an interview. Javad Parvizi, MD is a professor of Orthopedic Surgery at Rothman Institute at Thomas Jefferson University. He has been in practice for over 15 years, doing mostly hip and knee replacement with an interest in periprosthetic joint infection. “We are in desperate need of innovation that will help us to do better for these patients,” Dr. Parvizi told us. “But what we also face is diagnosis of periprosthetic joint infection is very difficult. It is difficult for two reasons.
Disruptive new multicenter research has determined that next generation sequencing (NGS) can reliably predict treatment failure due to periprosthetic joint infection (PJI). MicroGenDX, the High Complexity Laboratory utilized in the study, is upending outdated approaches to infection detection, instead relying on the most up-to-date technologies to not only determine that an infection is present, but to identify the exact micro-organism(s) involved.
Bone Joint J. 2018;100-B(2):127-133. Study: In a prospective, single-blinded study, periprosthetic joint infection was assessed in 86 synovial fluid samples from patients undergoing aspiration of the hip or knee. Next-generation sequencing (NGS) identified periprosthetic microbial pathogens in both culture-positive and culture-negative samples of synovial fluid. Unlike culture results, NGS detected antibiotic resistant pathogens in four cases; in 10 culture-negative samples, NGS identified positive results. Read Study…