Tarabichi M, Shohat N, Goswami K, Parvizi J.
Can Next Generation Sequencing Play a Role in Detecting Pathogens in Synovial Fluid?.

Bone Joint J. 2018;100-B(2):127-133.

Study: In a prospective, single-blinded study, periprosthetic joint infection was assessed in 86 synovial fluid samples from patients undergoing aspiration of the hip or knee. Next-generation sequencing (NGS) identified periprosthetic microbial pathogens in both culture-positive and culture-negative samples of synovial fluid. Unlike culture results, NGS detected antibiotic resistant pathogens in four cases; in 10 culture-negative samples, NGS identified positive results. Read Study

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