Comparative Effectiveness Randomized Clinical Trial Using Next-generation Microbial Sequencing to Direct Prophylactic Antibiotic Choice Before Urologic Stone Lithotripsy Using an Interprofessional Model

European Urology Open Science 57 (2023) 74-83

Article: A clinical trial examined the use of microbial DNA sequencing to guide antibiotic prophylaxis in patients undergoing kidney stone surgery who had no bacteria detected in standard urine cultures. The study found that this approach significantly reduced the risk of postoperative urinary infections compared to the standard of care, with a 7.1% reduction in infection risk in one analysis and an 8.5% reduction in another. Read Study Here

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