An Enhanced Understanding of Culture-Negative Periprosthetic Joint Infection With Next-Generation Sequencing

AN ENHANCED UNDERSTANDING OF CULTURE-NEGATIVE PERIPROSTHETIC JOINT INFECTION WITH NEXT-GENERATION SEQUENCING

Orthopaedic Proceedings

Research Article: In this prospective study samples were collected in 238 consecutive patients undergoing revision total hip and knee arthroplasties. Of these 83 patients (34.9%) had PJI, as determined using the Musculoskeletal Infection Society (MSIS) criteria, and of these 20 were culture-negative (CN-PJI). Synovial fluid, deep tissue and swabs were obtained at the time of surgery and sent for NGS and culture/MALDI-TOF. Read Article

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